Field and greenhouse experiments in 1981 and 1982 determined the potential interactions of three preemergence and three postemergence herbicides with four granular insecticides in soybeans [Glycine max (L.) Merr.]. Generally, metribuzin [4-amino-6-tert-butyl-3-(methylthio)-as-triazin-5(4H)-one] increased soybean injury and lowered yields when applied to plots treated with an organophosphate insecticide at planting. Soybean injury from these treatments and from aldicarb [2-methyl-2-(methylthio)-propionaldehyde-o-(methylcarbamoyl)oxime] plus metribuzin applied in the field was greater in 1982 than 1981 due to excessive rainfall immediately after planting. Oryzalin (3,5-dinitro-N4,N4 -dipropylsulfanilamide) plus several of the in-furrow insecticide treatments in the greenhouse increased injury to soybeans. Other than this, the method of insecticide application, banded or in-furrow, had no effect on that caused by each pesticide combination.